Dangerous liaisons: human genetic adaptation to infectious agents

Dangerous liaisons

Cells during mitosis and meiosis undergo chromosome condensation through a process that depends on evolutionary conserved large protein complexes known as condensins. There are two condensing complexes, condensin i and ii, each of which is composed of five subunits. Condensin i and ii play essential, yet distinct, roles in chromosome condensation and segregation during mitosis. Recent findings ...

Smoking and asthma: dangerous liaisons.

Cigarette smoking and asthma interact to induce important adverse effects on clinical, prognostic and therapeutic outcomes. This review examines recent evidence on the harmful effects of smoking in asthma, possible underlying inflammatory mechanisms for this altered response, management options for these patients and potential future therapeutic directions. Active smokers, particularly females,...

Ferritin and metallothionein: dangerous liaisons.

Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.

Dangerous liaisons? Industry relations with health professionals.

Tuberculosis, alcohol and tobacco: Dangerous liaisons.

The World Tuberculosis Day was celebrated in the past day of March 24. Despite sustained reduction in its incidence, tuberculosis (TB) still affects millions of patients, especially in certain group risks. Although its etiologic agent, most frequent risk factors, means to diagnosis, treatment and prevention are known, it persists as a relevant public health threat. The main determinants for the...